High-quality 4,4-Difluoro Benzhydryl Piperazine supplied by Macroline Health Care — a trusted exporter of Pharmaceutical APIs and Advance Intermediates with regulatory grade and documentation support.
Macroline Health Care supplies 4,4-Difluoro Benzhydryl Piperazine for pharmaceutical manufacturers and formulation partners worldwide. Below is a brief overview of the molecule and its commercial relevance.
4,4-Difluoro Benzhydryl Piperazine (CAS No. 27469-60-9) is a high-purity fluorinated piperazine derivative used as a pharmaceutical and fine chemical intermediate. It is also known as 1-(4,4'-Difluorobenzhydryl)piperazine and 1-[Bis(4-fluorophenyl)methyl]piperazine.
This compound is a useful building block for the synthesis of selected piperazine derivatives and pharmaceutical intermediates, including intermediates associated with Flunarizine- and Lomerizine-related synthesis routes.
Key technical parameters for quality evaluation, regulatory review, and sourcing decisions.
| Parameter | Specification / Value |
|---|---|
| Product Name | 4,4-Difluoro Benzhydryl Piperazine |
| Chemical Name | 1-(4,4'-Difluorobenzhydryl)piperazine |
| CAS Number | 27469-60-9 |
| EC Number | 248-476-0 |
| IUPAC Name | 1-[Bis(4-fluorophenyl)methyl]piperazine |
| Synonyms | 1-(4,4'-Difluorobenzhydryl)piperazine; 1-[Bis(4-fluorophenyl)methyl]piperazine; 4,4'-Difluorobenzhydrylpiperazine; Flunarizine Impurity A |
| Molecular Formula | C17H18F2N2 |
| Molecular Weight | 288.34 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | ≥98% |
| Melting Point | 88–92°C |
| Density | 1.146 g/cm³ (estimated) |
| Water Solubility | 0.34 g/L at 20°C |
| Category | Pharmaceutical Intermediate |
| Storage | Store at 15–25°C in a cool and dry place |
| Shelf Life | 2 Years |
| COA | Available |
| MSDS | Available |
Recommended packing and storage guidance to help maintain product integrity during export and warehousing.
| Parameter | Details |
|---|---|
| Packaging | Available in suitable pharmaceutical-grade packaging according to customer requirements and applicable transportation regulations. |
| Pack Size | To be confirmed based on customer requirements and current manufacturer specification. |
| Container | Properly sealed, labelled and suitable for pharmaceutical API storage and transportation. |
| Storage | Keep tightly closed and store according to the conditions specified in the approved product documentation / SDS. |
| Bulk Packaging | Bulk quantities can be arranged subject to availability and applicable packaging requirements. |
| Shelf Life | As specified by the manufacturer and supported by the applicable product documentation. |
Our team supports commercial inquiries, regulatory grade confirmation, COA/MSDS, and export documentation for pharmaceutical partners worldwide.